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In the mid-27th century, the Terran Confederation is at war with the felinoid Kilrathi Empire. After destroying a Terran base, the Kilrathi have seized a NAVCOM unit with the hyperspace jump coordinates to Earth. With Terran reinforcements scheduled to arrive two hours after the Kilrathi hit Earth, it falls upon the starfighter carrier TCS Tiger Claw to keep the Kilrathi busy.

Prot is a patient at a mental hospital who claims to be from a far away planet. His psychiatrist tries to help him, only to begin to doubt his own explanations.

In 1993, the Search for Extra Terrestrial Intelligence Project receives a transmission detailing an alien DNA structure, along with instructions on how to splice it with human DNA. The result is Sil, a sensual but deadly creature who can change from a beautiful woman to an armour-plated killing machine in the blink of an eye. Government agent Xavier Fitch assembles a team of scientists and mercenaries to locate and destroy Sil before she manages to find a mate and breed.

Sam Lowry is a harried technocrat in a futuristic society that is needlessly convoluted and inefficient. He dreams of a life where he can fly away from technology and overpowering bureaucracy, and spend eternity with the woman of his dreams. While trying to rectify the wrongful arrest of one Harry Buttle, Lowry meets the woman he is always chasing in his dreams, Jill Layton. Meanwhile, the bureaucracy has fingered him responsible for a rash of terrorist bombings, and both Sam and Jill's lives are put in danger.

The year is 2022, prison systems from all over the world are now run by private corporations and have become business. After being sentenced to life imprisonment for the murder of his commanding officer who ordered him to wipe out innocent people. Convicted soldier John Robbins is dumped on the prison island Absolom (after he refused to execute his cell-mate and assaulted the Warden). On Absolom, convicts are put there to either survive or die.

In 2046, in a research facility in Mars, some subjects are released and the place is kept in quarantine. A team of Marines, leaded by Sarge (The Rock), is assigned to rescue the personnel and retrieve the research data, with the support of Dr. Samantha Grimm (Rosamund Pike), the twin sister of the Marine John "Reaper" Grimm (Karl Urban). While in the mission, Samantha finds a dark hidden secret about the monsters and the researches.

Dr. Pretorius and his colleagues are working on a sensational experiment: by means of stimulation of the pineal gland, they want to open the human mind to higher dimensions. When the experiment succeeds, however, they are immediately attacked by terrible life forms, which apparently are floating around us all the time. When Dr. Pretorius is killed by one of them, Dr. Tillinghast is under suspect and thrown into the psycho ward due to his stories. Only the ambitious psychologist Dr. McMichaels believes him and wants to continue the experiment.

The Law Enforcement Technology Advancement Centre (LETAC) has developed SID version 6.7: a Sadistic, Intelligent, and Dangerous virtual reality entity which is synthesized from the personalities of more than 150 serial killers. LETAC would like to train police officers by putting them in VR with SID, but they must prove the concept by using prisoners as test subjects. One such prisoner is ex-cop Parker Barnes. When SID manages to inject his personality into a nano-machine android, it appears that Barnes might be the only one who can stop him.

Seth Brundle was a research scientist whose genes were fused with a housefly in a matter transmission experiment and he transformed into the terrifying mutant creature "Brundlefly" and the journalist who he fell in love with, Vernoica Quaife killed him by blowing out his brains with a shotgun. Veronica has died giving birth to Seth's son Martin. Martin is raised by Seth's evil employer Anton Bartok who requires Martin's help to solve the problems of the Telepods, believing the Telepods are the key for worldwide domination.

A genetic anomaly allows a young man to teleport himself anywhere. He discovers this gift has existed for centuries and finds himself in a war that has been raging for thousands of years between "Jumpers" and those who have sworn to kill them.